DNA assembly using bis-peptide nucleic acids (bisPNAs)
نویسندگان
چکیده
منابع مشابه
DNA assembly using bis-peptide nucleic acids (bisPNAs)
DNA nanostructures are ordered oligonucleotide arrangements that have applications for DNA computers, crystallography, diagnostics and material sciences. Peptide nucleic acid (PNA) is a DNA/RNA mimic that offers many advantages for hybridization, but its potential for application in the field of DNA nanotechnology has yet to be thoroughly examined. We report the synthesis and characterization o...
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Bis-peptide nucleic acid (bis-PNA) binding results in D-loop formation by strand displacement at complementary homopurine stretches in DNA duplexes. Transcription and replication in intact cells is mediated by multienzymatic complexes involving several proteins other than polymerases. The behaviour of the highly stable clamp structure formed by bis-PNAs has thus far been studied with respect to...
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The ideal scientist is one who thinks like a poet, but works like a bookkeeper. iv ACKNOWLEDGEMENTS I would first like to thank my advisor, Dr. Nick Hud, who over the years helped me develop my passion for science. The opportunity to work in his lab on the chemical origins of life was an eye-opening experience that will continue to influence my career for many years to come. I would also like t...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2002
ISSN: 1362-4962
DOI: 10.1093/nar/gkf389